Figure 7
Quantitative comparison of OCT guided micro-focal ERG measurements with multiple stimulation wavelengths in wild type and transgenic pigs. (A) Top: schematic of distribution of S and M cones in pig retina. (B) Quantitative comparison of A-wave amplitude of micro-focal ERG of S and M-cone photoreceptors stimulated by blue (B, 450 nm) and green (G, 520 nm) focused laser beam in wild type (WT) and transgenic (TG) pigs at light intensity 1000 (cd s/m2). (C) Quantitative comparison of B-wave amplitude of micro-focal ERG of S and M-cone photoreceptors stimulated by blue and green focused laser beam in WT and TG pigs at light intensity 1000 (cd s/m2). Red (638 nm) micro-focal stimulated ERG in WT and TG pigs shows roughly noise level amplitude only at 1000 (cd s/m2) indicating absence of L-cones. (D) Quantitative comparison of B-wave amplitude of micro-focal ERG of rod photoreceptors stimulated by blue and green focused laser beam in WT and TG pigs at different light intensities 0.1 and 1 (cd s/m2). N = 8 eyes/group. Graphs presented as mean ± SD, significance denoted by *P < 0.01 and **P < 1E−5 between wild type (WT) and transgenic (TG) groups.
