Figure 6
(a) Statistical analysis of the development of radiological signs of infection of all data demonstrated a significant change in all groups during the course of study till day 28 and also in between the study groups (p < 0.001). Here, the scorepoints of each examination group at each examination day after evaluation with the An et al. score are demonstrated. (b) Shows representative lateral x-rays of the left tibia of the group expl./syst. and gives an impression of the development of osteolysis during study course. The study group expl./syst. was scored with the highest points. First signs of osteolysis can be detected at day 7 (arrow). At day 14, signs of infection can be observed at the distal part of the tibia (arrow). The whole structure of the tibia has changed at day 28 due to bone infection with osteolysis of the complete bone, periosteal infection and pathologic fracture. (c) Shows representative lateral x-rays of the left tibia of each study group at the endpoint of the study at day 28. Signs of bone infection can be detected in all examination groups at day 28, especially group expl./syst. reveales massive osteolysis. Just genta/syst. shows very low signs of bone infection.
