Table 7 Diagnostic accuracy of the markers of infection.

From: Inflammation and nutrition based screening tests for detection of infection in cases of rapid hip destruction

Index

Cut-off

AUC (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

CRP, mg/L

> 10

0.99 (0.97–1.00)

1.00 (0.66–1.00)

0.87 (0.71–0.96)

0.72 (0.47–0.90)

1.00 (0.84–1.00)

ESR, mm/h

> 30

0.95 (0.90–1.00)

0.85 (0.55–0.98)

0.84 (0.68–0.94)

0.65 (0.38–0.86)

0.94 (0.80–0.99)

WBC count, 10*3/μL

> 7.3

0.69 (0.53–0.86)

0.69 (0.39–0.91)

0.68 (0.50–0.82)

0.43 (0.22–0.66)

0.86 (0.68–0.96)

Platelet count, 10*4/μL

> 3.3

0.86 (0.73–0.99)

0.77 (0.46–0.95)

0.84 (0.68–0.94)

0.63 (0.35–0.85)

0.91 (0.76–0.98)

Albumin, g/dL

< 4.0

0.93 (0.86–1.00)

1.00 (0.66–1.00)

0.73 (0.56–0.86)

0.57 (0.35–0.77)

1.00 (0.82–1.00)

AGR

< 1.1

0.96 (0.91–1.00)

0.92 (0.64–1.00)

0.95 (0.82–0.99)

0.86 (0.57–0.98)

0.97 (0.86–1.00)

CAR

> 4.56

0.99 (0.97–1.00)

1.00 (0.66–1.00)

0.92 (0.78–0.98)

0.81 (0.54–0.96)

1.00 (0.85–1.00)

GPS, points

> 0

0.97 (0.94–1.00)

1.00 (0.66–1.00)

0.81 (0.65–0.92)

0.65 (0.41–0.85)

1.00 (0.83–1.00)

mGPS, points

> 1

0.92 (0.85–0.99)

0.69 (0.39–0.91)

0.95 (0.82–0.99)

0.82 (0.48–0.98)

0.90 (0.76–0.96)

PNI

< 46.4

0.87 (0.77–0.97)

1.00 (0.66–1.00)

0.62 (0.44–0.78)

0.50 (0.30–0.70)

1.00 (0.77–1.00)

GNRI

< 98

0.81 (0.65–0.97)

0.69 (0.39–0.91)

0.81 (0.65–0.92)

0.56 (0.30–0.80)

0.88 (0.73–0.97

PLR

> 34.7

0.76 (0.58–0.94)

0.54 (0.25–0.81))

0.94 (0.80–0.99)

0.78 (0.40–0.97)

0.84 (0.69–0.94)

  1. AGR Albumin/globulin ratio, AUC Area under the curve, CAR CRP-albumin ratio, CI Confidence interval, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, GNRI Geriatric nutritional risk index, GPS Glasgow prognostic score, mGPS Modified Glasgow prognostic score, NPV Negative predictive value, PLR Platelet/lymphocyte ratio, PNI Prognostic nutrition index, PPV Positive predictive value, WBC White blood cell.