Figure 2 | Scientific Reports

Figure 2

From: Computational identification of new potential transcriptional partners of ERRα in breast cancer cells: specific partners for specific targets

Figure 2

Identification of a reduced set of TRs. (a) PCA (FactoMineR R package) on TR log2-expression across cell lines in each dataset. In the upper panels the scree plots show the selection of the 5 first principal components (37 to 44% of the total variance). The lower panels show the projection of the 50 best TRs taken as variables on the 2 first principal axes in each dataset. For each dataset, absolute value of correlation coefficient > 0.5 with each of the axes was taken as meaningful. (b) Venn diagram showing the selected TRs common to the 2 datasets. (c) Distributions of mean expression and of expression variation coefficient of the 318 selected TRs across cells in each dataset associated with boxplots. They show moderate expression of the majority of TRs with variation coefficient across cells mostly between 20 and 50% (inter-quartile range). (d) Boxplots showing ESRRA expression and variability in the BC cells of CCLE and GSE58135 datasets. (c, d) Expression is log2 of upper-quartile normalized TPM (for CCLE) or FPKM (for GSE58135) values.

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