Figure 7 | Scientific Reports

Figure 7

From: Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments

Figure 7

Proof of Concept steady states for each scenario. (A) First scenario: optimized network simulated with autologous conditioned serum (ACS). (B) Second scenario: Proinflammatory nodes of the optimized stimulation at their maximum capacity along with ACS stimulation to simulate an osteoarthritic joint or environment. (C) Third condition: proinflammatory nodes of the optimized stimulation at half of their maximum capacity along with ACS stimulation to simulate an osteoarthritic joint or environment with partial modulation of proinflammatory cytokines.

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