Figure 8 | Scientific Reports

Figure 8

From: Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments

Figure 8

Summarized methodology. (A) Workflow for the network design. The literature-based (LIT) network was built from available biological knowledge from specialized journals. Then, STRING21 was used to complement interactions, obtaining the enriched (ENR) network. Finally, a genetic algorithm (GA) and experimental data were used to tune the node interactions, leading to the optimized (OPT) network. (B) Illustration of how the steady state of the system is extracted from the dynamic information provided by the network calculations. (M&X is an acronym for the Mendoza et al.25 methodology).

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