Figure 7

PVP-I inhibits TLR4 and MyD88 complex formation in nasal polyps mouse model. (a) Bar graphs represent the relative expression of cytokines. Statistical significance: *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the control group; ^#P < 0.05, ^##P < 0.01 and ^###P < 0.001 compared with the LPS + PBS group; ^§P < 0.05, ^§§P < 0.01 and ^§§§P < 0.001 compared with the LPS + DEX group. (b) The expression of NLRP3, NF-κB-p65, caspase-1 and IL-1β were measured using an immunoblot in murine nasal mucosa tissues. Actin protein was used as a loading control. (c) Production of IL-1β in the nasal lavage fluid (NLF) were measured using the ELISA assay. Statistical significance: ***P < 0.001 compared with the control group; ^#P < 0.05 compared with the LPS + PBS group; ^§P < 0.05 compared with the LPS + DEX group.