Figure 1

Effect of LPS ip injection on the morphology of cortical microglia. Representative views of microglia in coronal sections of the cerebral cortex (dorso medial area), 24 h after i.p. injections with LPS or vehicle (Control). The cells were stained with anti-Iba1 antibody as described previously26. The LPS proinflammatory treatment resulted in changes in microglia cell morphologies including proximal thickening and increased short secondary branching of the cell processes leading to a “bushy like” appearance. Scale bar: 20 µm.