Figure 2
Centrality analysis for a single tissue system. (A) The total connectome for the pancreas is iteratively subset to each individual signaling family, after which Kleinberg hub and authority scores are calculated for each cell type. (B) Signaling families, grouped by dominant receiving nodes, crafts a quantitative portrait of global tissue system signaling architecture. In alignment with biologic intuition, mesenchymal cells are top network receivers of PDGF-family signals, epithelial cells are top network receivers of EGF-family signals, immune cells are top networks receivers of CSF- and CC (Chemokine)-family signals, and endothelial cells are in top network receiving positions for VEGF-, and ANGPT-family pathways. Centrality analysis was performed once for all signaling families, groupings were designated by top receiving node, and the four grouped plots were then individually re-made. Connectome v1.0.0 (available at github.com/msraredon/Connectome) was used to generate subfigures (A) and (B).
