Table 2 Morphometric analysis of whole wall and layer thickness (µm) in proximal and distal small (SI) and proximal large intestine (LI) as estimated on Htx-E stained sections from rats fed control (C), medium Maillard (MM) or high Maillard (HM) containing diets for 1 or 4 weeks.

From: Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants

  

Whole wall

p

Mucosa

p

Submucosa

p

Muscularis propria

p

1 week

Proximal SI

C

693.0 (658.0–731.8)

 

609.0 (570.0–643.0)

 

17.0 (14.5–18.8)

 

71.0 (61.5–76.0)

 
 

MM

661.5 (648.5–687.3)

ns

591.5 (566.0–602.0)

ns

15.5 (13.5–16.75)

ns

69.0 (59.3–81.0)

ns

 

HM

670.0 (635.5–739.8)

ns

588.0 (565.0–637.3)

ns

17.5 (16.3–18.8)

ns

70.0 (55.5–81.0)

ns

Distal SI

C

486.5 (484,0–516.8)

 

429.0 (413.0–448.8)

 

12.0 (11.3–13.5)

 

54.0 (48.8–61.5)

 
 

MM

492.5 (444.5–572.0)

ns

428.5 (382.8–486.3)

ns

13.0 (11.3–16.8)

ns

48.0 (43.5–65.3)

ns

 

HM

519.5 (460.3–571.3)

ns

439.5 (395.5–498.5)

ns

14.0 (12.0–16.8)

ns

56.0 (50.0–73.3)

ns

Proximal LI

C

469.5 (396.8–589.5)

 

246.5 (234.3–305.3)

 

45.5 (35.0–71.7)

 

184.0 (134.8–222.8)

 
 

MM

425.0 (391.8–427.5)

ns

229.0 (219.3–254.5)

ns

30.0 (22.3–37.0)

ns

150.5 (136.0–165.8)

ns

 

HM

433.0 (403.5–443.0)

ns

242.0 (230.0–248.0)

ns

29.5 (26.8–31.5)

ns

162.0 (144.0–165.0)

ns

4 weeks

Proximal SI

C

818.4 ± 51.7

 

715.4 ± 55.4

 

20.5 ± 4.1

 

77.1 ± 10.2

 
 

MM

736.6 ± 71.8)

0.0172

634.9 ± 59.8

0.0097

19.3 ± 3.0

ns

77.7 ± 18.6

ns

 

HM

686.9 ± 74

0.0002

601.8 ± 66.5

0.0004

17.9 ± 2.7

ns

68.3 ± 10.1

ns

Distal SI

C

592.0 ± 69.9

 

507.9 ± 63.4

 

19.4 ± 2.5

 

59 ± 6.8

 
 

MM

500.0 ± 06.5

0.0266

428.7 ± 84.7

0.0249

17.6 ± 3.1

ns

53.1 ± 13.6

ns

 

HM

485.6 ± 57.3

0.0102

410.3 ± 54.3

0.0056

16.9 ± 1.7

ns

52.7 ± 9.6

ns

Proximal LI

C

414.9 ± 49.3

 

215.5 ± 24.0

 

29.1 ± 2.1

 

170.7 ± 38.7

 
 

MM

420.5 ± 35.0

ns

213.6 ± 13.3

ns

26.6 ± 6.7

ns

179.8 ± 25.7

ns

 

HM

411.2 ± 35.8

ns

210.9 ± 18.5

ns

26.4 ± 3.9

ns

174.5 ± 19.4

ns

  1. Values from rats fed 1 week are expressed as median (interquartile range), n = 4, Kruskal–Wallis followed by Dunn´s multiple comparison test), Values from rats fed 4 weeks are expressed as mean ± SD, n = 10–11, one-way ANOVA followed by Dunnett´s multiple comparison test. P p value as compared to C, ns no significant differences compared to C.
Back to article page