Figure 2
From: Inhibition of RANKL and Sema4D improves residual ridge resorption in mice
Ovariectomy prolongs maxillary bone resorption after teeth extractions. (a) Ventral views (upper images) and lateral views (lower images) of μCT-3D images of the maxilla at day 0 (red) and 16 weeks (green) post-extraction of OVX mice are shown in the left and the middle images, respectively. The right image shows a superimposed illustration of day 0 and 16 weeks post-extraction. The arrows indicate decreased regions of the alveolar bone after 16 weeks post-extraction. (b) The graph shows the time-dependent changes in the bone volumes of the teeth-extracted side of the alveolar bone as described in Fig. 1a. Closed squares represent OVX mice and closed circles represent sham mice as the control. Data are expressed as mean ± S.D. (n = 3). (c) The graph shows the time-dependent changes in the ratio of the CT values of the maxilla alveolar bone of the extracted region (ROI-2) to the non-extracted buccal side (ROI-1) of the alveolar bone of OVX mice (closed square) and sham mice (closed circle), as described in Fig. 1b. The data shown in the graphs are representative of two independent experiments. ***P < 0.005; calculated using two-way ANOVA.
