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Figure 1

From: Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Figure 1

Whole-genome sequencing (WGS) was performed on the subjects in the nested case–control (NCC) study for islet autoimmunity (IA) and type 1 diabetes (T1D). In the NCC study, the “cases” were those subjects that had developed any IA (n = 389) or T1D (n = 118) and “controls” were randomly selected from those autoantibody-negative or non-T1D children in the index case’s risk set, matched for sex, clinical site and first-degree relative (FDR) status. Telomere length estimation was performed using five different tools. Single nucleotide polymorphisms (SNPs) were genotyped using the T1DExomeChip array. A total of 835 SNPs associated with telomere length were available on the T1DExomeChip and 236 of those had a minor allele frequency (MAF) > 0.05. SNP analysis was performed on 8093 TEDDY children.

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