Table 1 Length of telomeres (kb) in study subjects by the status of islet autoimmunity (IA) and type 1 diabetes (T1D) in the Environmental Determinants of Diabetes in the Young (TEDDY) study.

From: Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Parameter

Islet autoimmunity (IA)

Type 1 diabetes (T1D)

Matched pairs n (%)

IA cases (in kb)

IA controls (in kb)

Matched pairs n (%)

T1D cases (in kb)

T1D controls (in kb)

Country

Finland

63 (16.20%)

5.07 ± 0.76

5.22 ± 0.77

23 (19.49%)

5.09 ± 0.78

5.02 ± 0.93

Germany

13 (3.34%)

5.13 ± 0.65

5.52 ± 1.08

5 (4.24%)

5.39 ± 0.96

5.40 ± 0.27

Sweden

182 (46.78%)

5.13 ± 0.76

4.94 ± 0.84

49 (41.53%)

5.22 ± 0.87

5.05 ± 1.05

U.S.A.

131 (33.68%)

5.24 ± 0.78

5.35 ± 0.84

41 (34.74%)

5.16 ± 0.73

5.09 ± 0.84

Family history of T1D

First-degree relative

79 (20.31%)

5.19 ± 0.64

5.19 ± 0.81

25 (21.19%)

5.27 ± 0.84

5.07 ± 0.81

General population

310 (79.69%)

5.15 ± 0.79

5.13 ± 0.87

93 (78.81%)

5.16 ± 0.80

5.07 ± 0.96

Sex

Female

169 (43.44%)

5.23 ± 0.73

5.21 ± 0.88

52 (44.07%)

5.28 ± 0.75

5.09 ± 0.96

Male

220 (56.56%)

5.10 ± 0.78

5.10 ± 0.84

66 (55.93%)

5.10 ± 0.84

5.06 ± 0.91

  1. Telomere length data were available on both case and matched control subjects in 389 IA pairs and 118 T1D pairs. Computel was used to estimate the telomere length from the whole-genome sequence (WGS) data.
  2. Telomere length is presented as mean ± standard deviation (S.D.) in kb.