Table 2 Association between telomere length and characteristics of the subjects (sex, high risk HLA-DR-DQ haplogenotypes, country, first-degree relative (FDR) with T1D, gestational diabetes in the mother and parental age).

From: Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Parameter

Regression coefficient

Standard error

P-value

Child’s age (years)

− 0.029

0.0097

0.003

Sex

 Female

0.083

0.0458

0.069

High risk HLA-DR-DQ haplogenotypes

 HLA-DR3/3 or HLA-DR3/9

Reference

Reference

Reference

 HLA-DR3/4

0.105

0.0647

0.106

 HLA-DR4/4 or HLA-DR4/X

0.179

0.0675

0.008

Country

 U.S.A.

Reference

Reference

Reference

 Finland

− 0.137

0.0671

0.041

 Germany

− 0.100

0.1279

0.432

 Sweden

− 0.191

0.0548

0.001

FDR with T1D

General population

Reference

Reference

Reference

 Father

0.109

0.0771

0.157

 Mother

− 0.044

0.0985

0.653

 Sibling

− 0.054

0.1203

0.653

Gestational diabetes in the mother

0.094

0.0943

0.317

Parental age

 Maternal age (years)

0.002

0.0064

0.792

 Paternal age (years)

0.013

0.0055

0.019

  1. Telomere length data were available on a total of 1119 TEDDY children. The age at sample collection and the indicator of the long-distance protocol sample collection (yes vs. no) were also included in the model.
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