Table 3 Association between age-adjusted telomere length in subjects by the status of islet autoimmunity (IA, GADA-first or mIAA-first) and T1D in relation to HLA haplogenotypes.
HLA status | Odds ratio (95% CI) | P-value |
|---|---|---|
Any IA (n = 389 NCC pairs) | ||
Age-adjusted telomere length | 0.91 (0.75–1.12) | 0.377 |
HLA-DR3/3 or HLA-DR3/9 | Reference | Reference |
HLA-DR3/4 | 1.85 (1.23–2.78) | 0.003 |
HLA-DR4/4 or HLA-DR4/X | 1.30 (0.84–2.02) | 0.236 |
mIAA-first (n = 159 NCC pairs) | ||
Age-adjusted telomere length | 1.23 (0.87–1.73) | 0.248 |
HLA-DR3/3 or HLA-DR3/9 | Reference | Reference |
HLA-DR3/4 | 3.73 (1.70–8.17) | 0.001 |
HLA-DR4/4 or HLA-DR4/X | 2.59 (1.16–5.78) | 0.020 |
GADA-first (n = 158 NCC pairs) | ||
Age-adjusted telomere length | 0.83 (0.60–1.14) | 0.248 |
HLA-DR3/3 or HLA-DR3/9 | Reference | Reference |
HLA-DR3/4 | 0.91 (0.51–1.63) | 0.762 |
HLA-DR4/4 or HLA-DR4/X | 0.69 (0.36–1.33) | 0.266 |
T1D (n = 118 NCC pairs) | ||
Age-adjusted telomere length | 1.03 (0.75–1.42) | 0.861 |
HLA-DR3/3 or HLA-DR3/9 (Reference) | Reference | Reference |
HLA-DR3/4 | 2.22 (0.97–5.10) | 0.060 |
HLA-DR4/4 or HLA-DR4/X | 1.63 (0.71–3.73) | 0.249 |
