Figure 1 | Scientific Reports

Figure 1

From: Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy

Figure 1

Metabolite profiling of motor cortex revealed dysregulated metabolite due to TDP-43 pathology. (a) representative electron microscopy images of mitochondria in WT healthy CSMN and in CSMN that are diseased due to TDP-43 pathology (b) schematic representation of workflow of study design. (c) list of selected upregulated metabolites. (d) List of selected downregulated metabolites. Scale bar = 200 nm.

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