Figure 5 | Scientific Reports

Figure 5

From: Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy

Figure 5

Nicotinamide mononucleotide (NMN) improves the health of CSMN that become diseased due to TDP-43 pathology. (a) a representative image of CSMN from prpTDP-43A315T-UeGFP mouse; (b) a representative image of CSMN from prpTDP-43A315T-UeGFP mouse treated with 1 µM NMN; (c) a representative image of CSMN from WT-UeGFP mouse; (d) a representative image of CSMN from WT-UeGFP mouse treated with NMN. (e) Bar graph representation of average neurite length; (f) Percent distribution of axon length; and (g) Sholl analysis of arborization of neurites. Scale bar = 20 µm.

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