Figure 1

DPN Transcriptome: (A) Scatterplot of all DEGs where dysregulated genes with high log2 fold change per base mean of normalized DESeq2 counts are highlighted. Immunoglobulins and other inflammatory related genes are upregulated while some genes involved in neurogenesis like the transcription factors SCRT1 and TLX3 were downregulated in the diabetic individuals. (B) Heatmap of all 844 DEGs. (C-E) H and E images of the L4 DRG, scale bar = 500 µm; (C) Normal dorsal root ganglion with adequate density of ganglion cells surrounded by satellite cells, (D) DPN with a neuropathologist report of moderate loss of neuronal ganglion cells with replacement reactive fibrosis, and (E) DPN with a neuropathologist report of severe loss of neuronal ganglion cells with replacement fibrosis (hematoxylin and eosin stains at 40X magnification).