Figure 2

Heatmaps of dysregulated genes belonging to functional protein classes associated with pain signaling. Pictured are heatmaps of (A) transcriptional regulators and (B) kinases. Inflammation can cause gene expression changes in nociceptors through downstream intracellular signaling cascades that ultimately activate various transcription factors. Inflammatory signaling can additionally stimulate protein kinases that can then modulate pain transducing ion channels to induce peripheral sensitization.