Figure 4 | Scientific Reports

Figure 4

From: Structure and activity of the DHNA Coenzyme-A Thioesterase from Staphylococcus aureus providing insights for innovative drug development

Figure 4

Putative active sites of the tetrameric SaDHNA-CoA thioesterase. (a) Ribbon representation of SaDHNA (light pink) superimposed with the 4-hydroxybenzoyl-CoA thioesterase D17N mutant structure of Pseudomonas (PDB code 1LO9) (light grey). The substrate 4-hydroxybenzoyl-CoA (BCA) complexed with the D17N Ps4HBT mutant is shown in stick representation; carbon in cyan; sulfur in yellow; phosphate in orange, nitrogen in blue, oxygen in red; “N” and “C” indicate N- and C-terminus, respectively. (b) Residues at the proposed active site region with assigned thioesterase activity of SaDHNA (pink), Pseudomonas 4HBT structure (yellow) and hypothetical thioesterase from Thermus. thermophilus (pdb code 1Z54) (light gray). Italic amino acid residue labels indicate corresponding residues in the Pseudomonas 4HBT structure (yellow).

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