Figure 2

(A) Kernel density plots for the feature used to generate the GMM grouping before and after harmonization by the GMM groupings. B) Representative kernel density plots for the original features and after applying standard ComBat and harmonizing by the GMM grouping alone (GMM). C) Representative kernel density plots for the original features and after harmonizing by both the GMM grouping and known imaging parameter batch effects (GMM + ComBat (CE)). Kernel density plots represent ComBat results separated by the batch variable contrast enhancement, where nCE indicates no enhancement and CE indicates enhancement. For (B) and (C), representative features whose distributions best visually demonstrate the effects of GMM ComBat were selected by screening all the feature distributions before and after harmonization. Harmonization should result in more similar feature distributions.