Figure 4
From: Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis
3D Models of pirfenidone binding to MAPK12 and furin. (A) 2D and 3D structure of pirdenidone; (B) Pirfenidone docking site with MAPK12. Pirfenidone seems to attach more strongly at the Ala146 residue in the conserved region and near active binding sites; (C) Pirfenidone docking site with furin. Pirfenidone has a much higher binding affinity for the human model of furin than the mouse model. Pirfenidone appears to bind at the catalytic domain at the Val 290 residue.
