Table 3 List of the 10 most potent ligands for MAPK12 and all known inhibitors of Furin binding affinities compared with pirfenidone.
From: Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis
Ligand | Type | pKd value | |
|---|---|---|---|
MAPK12 | Pirfenidone* | Inhibitor | 10.66 |
Doramapimod | Inhibitor | 8.5 | |
AST-487 | Inhibitor | 7.5 | |
Staurosporine | Inhibitor | 7.4 | |
Lestaurtinib | Inhibitor | 6.4 | |
Tamatinib | Inhibitor | 6.4 | |
Foretinib | Inhibitor | 6.4 | |
SB203580 | Inhibitor | 5.8 | |
Linifanib | Inhibitor | 5.7 | |
Ruboxistaurin | Inhibitor | < 5.5 | |
Erlotinib | Inhibitor | < 5.5 | |
Furin | Pirfenidone* | Inhibitor | 24.47 |
MI-1148 | Inhibitor | 11.3 | |
Phenylacetyl-Arg-Val-Arg-4-Amidinobenzylamide | Inhibitor | 9.1 | |
Peptide 18 | Inhibitor | 8.4 | |
Furin inhibitor peptide | Inhibitor | 7.6 |
