Table 1 Differentially expressed genes in normal and HCM IVS cells.
Gene of interest | Affected cell group | Expression in HCM | Established HCM gene | |
|---|---|---|---|---|
1 | ACTA1 | Neuronal | Increased | |
2 | ACTC1 | Cardiomyocyte | Increased | Yes |
3 | ADH1B | Cardiomyocyte cluster 8 | Decreased | |
4 | C1R | Fibroblast | Decreased | |
5 | C1S | Fibroblast | Decreased | |
6 | C7 | Fibroblast | Decreased | |
7 | CCL2 | Neuronal | Decreased | |
8 | CFD | Endothelial cluster 1 | Increased | |
9 | CILP | Fibroblast | Decreased | |
10 | COL1A1 | Fibroblast | Decreased | |
11 | COL6A1 | Fibroblast | Decreased | |
12 | COL6A2 | Fibroblast, lymphatic | Decreased | |
13 | CYR61 | Fibroblast clusters 2, 4, 7 | Decreased | |
14 | FOS | Leukocyte | Decreased | |
15 | HES1 | Fibroblast | Decreased | |
16 | IGFBP7 | Fibroblast | Decreased | |
17 | JUNB | Cardiomyocyte | Decreased | |
18 | MFAP4 | Fibroblast | Decreased | |
19 | MS4A6A | Cardiomyocyte | Decreased | |
20 | MYH7 | Cardiomyocyte | Increased | Yes |
21 | MYL2 | Myofibroblast, smooth muscle, neuronal | Increased | Yes |
22 | NEAT1 | Cardiomyocyte, cardiomyocyte cluster 1 & 6, pericyte | Decreased | |
23 | PMEPA1 | Neuronal | Decreased | |
24 | POSTN | Fibroblast, endothelial | Decreased | |
25 | S100A1 | Smooth muscle | Increased | |
26 | SERPINF1 | Fibroblast | Decreased | |
27 | TNNI3 | Cardiomyocyte, smooth muscle | Increased | Yes |
28 | TNNT2 | Myofibroblast, lymphatic | Increased | Yes |
