Figure 4
From: Sexual dimorphic impacts of systemic vincristine on lower urinary tract function
In vitro physiological evaluation of the bladder strips. A, peak contractile force in response to electric field stimulation (EFS, left), carbachol (CCh, center), and αβ-MeATP and KCl (right) [N = 6, 12 bladder strips per group per sex]. B, peak contractile force in response to EFS at 32 Hz after preincubation of αβ-MeATP and atropine. The force was normalized with tissue weight and expressed as relative to the response to EFS in absence of inhibitors. Open and grey boxes represent the control and VCR group, respectively. C, the amplitude, and the frequency of spontaneous contractions of the bladder strips. Open and grey triangles represent female mice in the control and VCR groups, respectively [12 bladder strips per group]. Open and grey circles represent male mice in the control [12 bladder strips] and VCR [11 bladder strips] groups, respectively. Mean ± SE, *p < 0.05, **p < 0.005 vs. the control group. Figures were prepared using Adobe Photoshop CS6 and GraphPad Prism 8.4.3 (https://www.graphpad.com/scientific-software/prism/).
