Figure 3 | Scientific Reports

Figure 3

From: Zinc complex of 3,5-di-tert-butyl salicylate inhibits viability, migration, and invasion in triple-negative breast cancer cells

Figure 3

Gene expression changes in 4T1 cells after Zn{[CH3)3C]2Sal}22− treatment analyzed by RNA-seq. (A) Hierarchical clustering of differentially expressed mRNAs between control and Zn{[CH3)3C]2Sal}22− (25 μM)-treated 4T1 cells. (B) A volcano plot shows differentially expressed RNAs after treating 4T1 cells with Zn{[CH3)3C]2Sal}22−. (C) The enriched cell functional classifications for the DEGs in 4T1 cells after treatment with Zn{[CH3)3C]2Sal}22−. (D) The top 16 enriched pathways for the DEGs in 4T1 cells after treatment with Zn{[CH3)3C]2Sal}22−. (E) mRNA expression levels in Zn{[CH3)3C]2Sal}22–treated 4T1 cells verified by RT–PCR.

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