Table 3 Potential mRNA targets of candidate miRNAs within the AGAT metabolism. The analysis was performed using the online tools miRDB, miRWalk, TargetScan, and miRTarBase. For the individual databases, interactions were considered relevant when the following criteria were met: miRDB – target prediction score > 80; miRWalk – binding p-value > 0.9; TargetScan – conserved sites; miRTarBase – experimentally validated targets. All interactions which were predicted in at least three out of four of the online tools are listed in the table. CVD: cardiovascular disease; MI: myocardial infarction; n.a.: not applicable (no association with CVD reported).

From: Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice

miRNA

Target gene

miRWalk

TargetScan

miRDB

miRTarBase

Role in CVD

let-7i-5p

Ccnd2

X

X

X

 

Recovery after MI 45

Fign

X

X

X

 

Blood pressure and arterial hypertension46

Igf2bp2

X

X

X

 

Type 2 diabetes, physiology of cardiomyocytes47

miR-130a-3p

Memo1

X

X

X

 

n.a

miR-148a-3p

Phactr2

X

X

X

 

n.a

miR-204-5p

Efnb3

X

X

X

 

Blood pressure regulation48

Ezr

X

X

X

 

n.a

Chp1

X

X

X

 

n.a

Ociad2

X

X

X

 

n.a

Pde1c

X

X

X

 

Heart failure49

Fam126a

X

X

X

 

n.a

miR-298-5p

Igf1r

X

 

X

X

Atherosclerosis50

miR-30b-5p

Lgi1

X

X

  

n.a

Fign

X

X

X

 

Blood pressure and arterial hypertension46

Ddah1

X

X

X

 

Cardiac remodeling after MI51

miR-31-5p

Bahd1

X

X

X

 

n.a

miR-135a-5p

Prlr

X

X

X

 

n.a

Zfp385b

X

X

X

 

n.a

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