Figure 2 | Scientific Reports

Figure 2

From: Differential early diagnosis of benign versus malignant lung cancer using systematic pathway flux analysis of peripheral blood leukocytes

Figure 2

(A) Heatmap of the differentiated flux of 43 molecular pathways in three participant-groups; (B) top 6 pathways selected from the 43 molecular pathways from (A). (C) Boxplot of the immune-related index (IM-Index) for malignant (red), benign pulmonary nodules (green), as well as healthy controls (blue). The p-value obtained through the Kruskal–Wallis test showed statistical significance with p < 0.001. (D) ROC analysis results comparison of IM-Index (AUC: 0.822) and 5 lung cancer-specific biomarkers. (E) Boxplot of IM-Index comparison between malignant and benign subgroups in validation cohort; (F) ROC analysis of IM-Index in the validation cohort.

Back to article page