Figure 3

Schematic Immune-related Pathway Interaction Map and IM-Index. (A) A simplified overview of the abstract signaling interaction and crosstalk between different signaling and metabolic pathways in the artificial intelligent (AI) model. The map is termed PIML (pathway interaction map of leukocyte). Each element symbolizes a corresponding pathway containing up-, middle-, and downstream components including gene, RNA, protein, compound, and complex. (B–D) three PIMLs visualize these three groups with median IM-Index respectively.