Table 1 Characteristics of adult cohorts included in the primary meta-analysis.

From: DNA methylation in peripheral tissues and left-handedness

 

NTR adults

ALSPAC adults

N = 2682

N = 1232

LH

RH

LH

RH

N

324 (12%)

2358 (88%)

99 (8%)

1133 (92%)

Age at blood sampling

34.3 (11.2)

36.8 (12.9)

49.1 (5.9)

49.0 (5.5)

Sex

Males

119 (37%)

783 (33%)

31 (31%)

333 (29%)

Females

205 (63%)

1575 (67%)

68 (69%)

800 (71%)

Multiples

315 (97.2%)

2171 (92%)

0

0

BMI

24.2 (3.7)

24.2 (3.9)

25.80 (4.3)

26.71 (4.7)

Smoking (current)

65 (20%)

486 (21%)

37 (37%)

424 (37%)

Cell proportion

Neutrophils

B lymphocytes

52.8 (8.7)

52.4 (9.2)

10.8 (4.3)

10.4 (4)

Eosinophils

CD4T

3.1 (1.9)

3.1 (2.3)

18.4 (7.2)

18 (6.6)

Monocytes

CD8T

8.4 (2.2)

8.4 (2.4)

2.2 (3.8)

1.9 (3.1)

Natural killer cells

21.9 (6.5)

20.7 (5.7)

Granulocytes

 

45.5 (14.7)

47.9 (12.4)

Monocytes

7.5 (3.4)

7.4 (3.5)

  1. NTR Netherlands Twin Register, ALSPAC Avon Longitudinal Study of Parents and Children, LH left-handed, RH right-handed.
  2. Whole blood DNA methylation (Illumina 450 k). Numbers in EWAS basic models are reported.
  3. Values are presented as mean (standard deviation (SD)) or n (%).
  4. Current smokers in ALSPAC were defined as those with cg05575921 methylation below 0.82 (see “Methods”section).