Table 3 Top differentially methylated positions from EWAS meta-analysis of left-handedness.

From: DNA methylation in peripheral tissues and left-handedness

CpG

CHR

Positiona

Gene

Location

β

SE

P

FDR

Direction

cg22804475

8

20,054,597

ATP6V1B2

TSS200

− 0.0007

0.0002

1.28 × 10–06

0.197

–

cg09239756

12

106,642,360

CKAP4

TSS1500

− 0.0032

0.0007

1.82 × 10–06

0.197

–

cg22541911

12

51,785,465

GALNT6

TSS1500

− 0.0010

0.0002

1.90 × 10–06

0.197

–

cg13719901

3

46,608,139

LRRC2

5′UTR; TSS200

0.0081

0.0017

2.60 × 10–06

0.197

 +  + 

cg02850812

13

46,961,666

C13orf18

TSS200

− 0.0014

0.0003

2.62 × 10–06

0.197

–

cg16852837

18

51,750,955

MBD2

1st Exon; 5′UTR

− 0.0006

0.0001

3.28 × 10–06

0.205

–

cg09893588

20

61,340,109

NTSR1

TSS200

− 0.0011

0.0003

9.12 × 10–06

0.256

–

cg12402132

12

121,148,554

UNC119B

Gene body

− 0.0009

0.0002

9.54 × 10–06

0.256

–

  1. β is the regression coefficient for left-handedness in EWAS meta-analysis adjusted model that included NNTR adults = 2663 and NALSPAC adults = 1058.
  2. CpGs with uncorrected P-value < 1.0 × 10–5 are presented.
  3. CHR chromosome; SE standard error; FDR false discovery rate; TSS200 200 base pairs upstream of transcription start site;TSS1500 1500 base pairs upstream of transcription start site; 5′UTR 5′ untranslated region; +  +, positive direction of effect in each cohort; –, negative direction of effect in each cohort.
  4. aGenome build Hg19 (build 37). See additional information on CpGs in Supplementary Table 12.
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