Table 4 Significant differentially methylated regions associated with left-handedness in meta-analysis and secondary analysis.

From: DNA methylation in peripheral tissues and left-handedness

Cohort

Chromosome

Start

End

n CpGs

Genes

Effect size

SE

P

Padjust

Meta-analysis

NTR and ALSPAC adults (blood DNA methylation)

chr20

36,148,679

36,149,022

16

BLCAP, NNAT

− 0.153

0.024

9.80 × 10–11

4.31 × 10–05

chr2

9,614,471

9,614,744

7

IAH1

− 0.102

0.019

7.33 × 10–08

0.03

Secondary analysis

NTR children at 9 years (buccal cell DNA methylation)

chr8

145,024,929

145,025,064

4

PLEC1

− 0.056

0.008

1.07 × 10–11

9.14 × 10–06

chr22

36,011,405

36,011,843

2

MB

− 0.119

0.022

4.09 × 10–08

0.035

chr9

111,696,674

111,697,545

10

EELP1, ABITRAM

− 0.134

0.024

4.59 × 10–08

0.039

chr12

899,323

899,559

2

WNK1

− 0.117

0.021

4.69 × 10–08

0.040

  1. Effect size is a weighted sum of the EWAS effects for each CpG site in the DMR (i.e. methylation differences between LH and RH) where the weights account for dependence between CpG sites and uncertainty in the EWAS effects (see “Methods” section). Nmeta-analysis = 3721, NNTR children = 866.
  2. NTR Netherlands Twin Register. ALSPAC Avon Longitudinal Study of Parents and Children. SE standard error; Padjust P-value multiplied by the total number of tests performed; the number of tests is equal to the number of regions for which DMR statistics are calculated.
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