Figure 2

Schematic of tissue permeability dependence on volume changes that arise from the balance of fluid pressure and solid-state stress. A zero solid-state stress condition on the left is assumed to occur when IFP is near atmospheric pressure in the absence of external loading. Changes in either IFP or solid stress can change the pore space through which fluid can percolate leading to higher flow rates with the same gradient in IFP. Under conditions of sufficient solid-state compression on the right, the flow paths are highly restricted leading to minimal flow and the potential for increased fluid pressure.