Table 2 Top-ten most significant-enriched gene sets according to NES value ranking of GSEA results positively and negatively correlated with DEGs, respectively.
No | Significant-enriched genes sets | Correlation | NES |
|---|---|---|---|
1 | REACTOME_TNF_RECEPTOR_SUPERFAMILY_TNFSF_MEMBERS_MEDIATING_NON_CANONICAL_NF_KB_PATHWAY | Positive | 1.90 |
2 | BIOCARTA_CTL_PATHWAY | Positive | 1.90 |
3 | BIOCARTA_TCYTOTOXIC_PATHWAY | Positive | 1.86 |
4 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION | Positive | 1.85 |
5 | REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS | Positive | 1.84 |
6 | BIOCARTA_NO2IL12_PATHWAY | Positive | 1.82 |
7 | REACTOME_PIWI_INTERACTING_RNA_PIRNA_BIOGENESIS | Positive | 1.80 |
8 | BIOCARTA_THELPER_PATHWAY | Positive | 1.79 |
9 | REACTOME_SURFACTANT_METABOLISM | Positive | 1.78 |
10 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Positive | 1.77 |
11 | PID_INTEGRIN1_PATHWAY | Negative | −2.22 |
12 | REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES | Negative | −2.16 |
13 | REACTOME_RESPONSE_TO_METAL_IONS | Negative | −2.07 |
14 | REACTOME_COLLAGEN_FORMATION | Negative | −2.06 |
15 | WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING | Negative | −2.02 |
16 | REACTOME_SIGNALING_BY_NODAL | Negative | −2.02 |
17 | WP_MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS | Negative | −2.00 |
18 | REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES | Negative | −1.98 |
19 | REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS | Negative | −1.97 |
20 | REACTOME_LAMININ_INTERACTIONS | Negative | −1.94 |
