Figure 1

Effect of valsartan and LCZ696 on the serum cardiac troponin T levels in doxorubicin-treated rats. (A) On day 11, DOX significantly increased the serum cardiac troponin T level, which did not differ from that in the DOX + VAL and DOX + LCZ groups. n = 15 in each group. (B) On day 18, the increased serum cardiac troponin T level in the DOX group was significantly reduced in the DOX + LCZ group, but not in the DOX + VAL group. n = 10–15 in each group. Data are expressed as the mean ± standard error. *p < 0.05 versus control and ^#p < 0.05 versus DOX. MDA, malondialdehyde; DOX, doxorubicin; VAL, valsartan; LCZ, LCZ696.