Figure 3 | Scientific Reports

Figure 3

From: Coating Ti6Al4V implants with nanocrystalline diamond functionalized with BMP-7 promotes extracellular matrix mineralization in vitro and faster osseointegration in vivo

Figure 3

The metabolic activity (a) and the activity of alkaline phosphatase (ALP) (b) of hFOB 1.19 cells cultured on bare Ti6Al4V samples (Ti6Al4V), on Ti6Al4V samples coated with the O-terminated nanocrystalline diamond coating (O-NCD), or on Ti6Al4V samples coated with the O-terminated nanocrystalline diamond coating functionalized with BMP-7 (O-NCD + BMP-7) under differentiation conditions (a restrictive temperature of 39.5 °C) for 3 weeks. Mean ± S.E.M. * indicates a significant difference from the reference Ti6Al4V, while # shows a significant difference from the O-NCD coating; p < 0.05.

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