Figure 2
High-throughput drug screen to assess collateral responses to doxorubicin resistance. Cell lines screened are in columns, drugs with collateral effects are in rows. Colors represent the log2 fold change of the EC50 of each cell line for a drug relative to the parental cell line’s EC50 for that same drug. Red represents a case in which the resistant cell line also acquired resistance to a different drug—collateral resistance. Blue represents a case in which the resistant cell line acquired sensitivity to a different drug—collateral sensitivity.
