Figure 2 | Scientific Reports

Figure 2

From: Vitiligo-specific soluble biomarkers as early indicators of response to immune checkpoint inhibitors in metastatic melanoma patients

Figure 2

Serum levels of CXCL9, CXCL10, and CXCL11 in melanoma patients treated with CPIs. Chemokine levels were analyzed by ELISA in serum samples of melanoma patients before (T0) and after 1 month (T1) and 3 months (T2) of treatment. Best overall response according to iRECIST criteria: iPD, progressive disease (n. 13 patients); iSD, stable disease (n. 16 patients); iPR, partial response (n. 17 patients); complete response, iCR (n. 11 patients). (a,b) CXCL9, (c,d) CXCL10, (e,f) CXCL11 amount (pg/ml). Data are indicated as mean value ± standard error of the mean (SEM). *p < 0.05, as assessed by Mann–Whitney U test to compare between-group differences; or by Wilcoxon signed-rank test to evaluate before–after treatment differences.

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