Table 1 Clinicopathologic features of patients diagnosed with colorectal cancer showing high and low Smad ubiquitination regulatory factor 2 (Smurf2) expression.
From: Tumor-suppressive role of Smad ubiquitination regulatory factor 2 in patients with colorectal cancer
| Â | Smurf2 expression | P value | |
|---|---|---|---|
High (n = 31) | Low (n = 35) | ||
Age at primary surgery (years), Median (range) | 69 (50–82) | 65 (46–81) | 0.0952 |
Gender, Male/Female | 21/10 | 23/12 | 1.0000 |
Site of tumor, Colon/Rectum | 19/12 | 21/14 | 1.0000 |
Site of tumor, Right/Left/Rectum | 6/13/12 | 13/8/14 | 0.1577 |
Degree of differentiation, tub, pap/por, muc | 30/1 | 32/3 | 0.6161 |
Ly, 0–1/2–3 | 27/4 | 28/7 | 0.5207 |
V, 0–1/2–3 | 16/15 | 15/20 | 0.6217 |
T stage (8th edition), 1/2/3/4 | 1/0/17/13 | 0/2/17/16 | 0.5423 |
Lymph node metastasis, + / −  | 17/14 | 22/13 | 0.6177 |
CEA, median (range) | 8 (1.4–5610) | 6.9 (0.7–5700) | 0.8786 |
CA19-9, median (range) | 12 (0.1–702) | 33.3 (0–16,200) | 0.1561 |
KRAS mutation, Wild/Mutant | 9/4 | 9/7 | 0.7021 |
Adjuvant chemotherapy, + / −  | 5/26 | 5/30 | 1.0000 |
Interval to liver metastasis (months), mean ± SD | 6.0 ± 1.9 | 5.1 ± 1.8 | 0.7820 |
Timing of metastasis, Synchronous/metachronous | 17/14 | 22/13 | 0.6177 |
Number of liver metastatic tumors, mean ± SD | 2.9 ± 0.5 | 3.0 ± 0.5 | 0.8808 |
Number of liver metastatic tumors, Solitary/Multiple | 10/21 | 13/22 | 0.7973 |
Size of liver metastatic tumors (cm), mean ± SD | 3.2 ± 0.4 | 4.3 ± 0.4 | 0.0877 |
Site of liver metastasis, Unilateral/Bilateral | 17/14 | 20/15 | 1.0000 |
Hepatectomy, Minor/Major | 28/3 | 28/7 | 0.3138 |
H factor, H1/H2/H3 | 24/7/0 | 19/15/1 | 0.0914 |
Extrahepatic metastases, + / −  | 6/25 | 6/29 | 1.0000 |
