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Figure 1

From: Doxycycline prevents blood–brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury

Figure 1

Molecular docking studies demonstrating doxycycline interaction with MMP-9 protein (PDB ID: 4XCT). Doxycycline interacting with active site residues of MMP-9 protein shown in sticks representation (a). MMP-9 surface map and the binding of Doxycycline in its active site cleft (b). 2D-interaction diagram of Doxycycline with MMP-9 protein showing hydrogen bonding, metal–ligand and hydrophobic interactions (c). Table quantifying and describing molecular docking based atomic level interactions between MMP-9 active site residues and doxycycline (d).

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