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Features of the four novel candidate causal variants. Note the predicted protein changes of the detected variants indicated in red. ((A) KIR2DS1:p.Gln159*82, (B) NOTCH3:p.Cys44del76, (C) RIOX1:p.Ala133_Glu142del83, (D) PCDH15:p.Leu867Val84).