Table 4 The events leading the discontinuation of anti-TNF treatment.

From: Elderly onset age is associated with low efficacy of first anti-tumor necrosis factor treatment in patients with inflammatory bowel disease

Events

Non-elderly

n = 352

Elderly

Elderly-NEO

n = 25

Elderly-EO

n = 55

n

n/1000 py

n

n/1000 py

n

n/1000 py

Lack of effectiveness

89

132

9

131

20

291

 Primary non-response

25

40

3

44

9

164

 Loss of response

64

92

6

87

11

127

SAEs

44

45

3

40

14

127

 Infection

3

3

0

0

2

18

 Infusion reaction

17

17

1

13

1

9

 Exanthema

5

5

1

13

1

9

 Lupus-like syndrome

7

7

0

0

1

9

 Interstitial pneumonia

0

0

0

0

1

9

 Thrombocytopenia

0

0

0

0

1

9

 Hepatic dysfunction

2

2

1

13

0

0

 Renal dysfunction

2

2

0

0

0

0

 Cardiovascular event

2

2

0

0

1

9

 Malignancy

2

2

0

0

2

18

 Death

2

2

0

0

3

27

 Others

3

3

0

0

1

9

  1. Anti-TNF anti-tumor necrosis factor, EO elderly onset, IBD inflammatory bowel disease, NEO non-elderly onset, py patient-years, SAEs severe adverse events.
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