Figure 2
From: A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens
Genomic stability analysis. (a) Correlation density plot of the VAF for all non-synonymous variants at T0 in standard 80% ECM conditions with all other time points in both culture conditions, for the three colon models (top) and three oesophageal models (bottom). (b) Percentage concordance of mutations with a VAF greater than 0.05 for each model with associated Jaccard index scores at T1 and T2. Total somatic variant count at T1 and T2 is indicated with an (x) and is shown on the secondary y-axis. (c) Intogen database filtered cancer-specific driver gene VAF heat maps for colon samples (left) and oesophageal samples (right).
