Table 3 Comparisons of computed tomographic findings between subgroups defined based on symptoms and physical activity questionnaires.

From: Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease

 

Less symptomatic (CAT < 10)

Symptomatic (CAT ≥ 10)

 

LSA > 60

(n = 82)

LSA ≤ 60

(n = 11)

LSA > 60

(n = 73)

LSA ≤ 60

(n = 27)

In-LAV950%, %

13.0 ± 11.6

8.8 ± 9.2

15.9 ± 12.3†

23.5 ± 14.2*†‡

Ex-LAV856%, %

42.0 ± 18.1

29.5 ± 14.8

46.0 ± 18.5

60.1 ± 11.7*†‡

SAD%, %

26.9 ± 11.5

18.8 ± 10.0

28.4 ± 11.2

35.8 ± 11.0*†‡

WA%, %

63.9 ± 3.6

63.2 ± 2.4

65.1 ± 3.6

63.9 ± 2.7

CLE, n (%)

40 (49%)

5 (45%)

43 (59%)

21 (78%)

PSE, n (%)

42 (51%)

4 (36%)

28 (38%)

16 (59%)

TLCCT, % predicted

94.9 ± 14.0

86.8 ± 14.0

95.9 ± 14.1

93.7 ± 14.8

FRCCT, % predicted

111.0 ± 25.8

88.6 ± 15.7

115.0 ± 30.0†

125.0 ± 23.4†

PM index, cm2 /m2

10.5 ± 2.4

9.1 ± 1.2

10.3 ± 3.0

8.4 ± 2.7*‡

SAT index, cm2 /m2

10.1 ± 3.9

10.6 ± 3.0

10.6 ± 4.6

6.7 ± 3.9*†‡

ESM index, cm2 /m2

12.0 ± 2.5

11.5 ± 2.1

12.1 ± 3.0

10.5 ± 2.5‡

BMD, HU

159.2 ± 43.6

101.0 ± 36.7*

147.0 ± 48.6†

144.0 ± 49.7†

Agatston score > 400, n (%)

19 (23%)

3 (27%)

22 (30%)

8 (30%)

  1. Data are expressed as mean ± SD and n (%). Based on scores of COPD assessment test (CAT) and Life-Space Assessment (LSA) questionnaires, patients were divided into 4 groups. In-LAV950% = low attenuation volume percentage on inspiratory CT. Ex-LAV856% = low attenuation volume percentage on expiratory CT (air-trapping index). SAD% = non-emphysematous air-trapping percentage (small airway dysfunction) on inspiratory/expiratory CT. WA% = wall area percent. CLE = centrilobular emphysema. PSE = paraseptal emphysema. TLCCT = total lung volume on inspiratory CT adjusted by reference total lung capacity value. FRCCT = total lung volume on expiratory CT adjusted by reference functional residual capacity value. PM index = cross-sectional area of pectoralis muscle that was normalized by height. SAT index = cross-sectional area of subcutaneous adipose tissue adjacent to pectoralis muscle that was normalized by height. ESM index = cross-sectional area of erector spinae muscle that was normalized by height. BMD = thoracic vertebral bone mineral density. Agatston score = coronary artery calcification score. * p < 0.05, †p < 0.05, and ‡ p < 0.05 compared to patients with CAT < 10 and LSA > 60, to those with CAT < 10 and LSA ≤ 60, and to those with CAT ≥ 10 and LSA > 60, respectively, based on the Tukey’s method for continuous variables and Fisher’s exact tests with Bonferroni correction for categorical variables.
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