Figure 4
From: Promiscuity mapping of the S100 protein family using a high-throughput holdup assay
Promiscuity of the S100ome towards the H14 foldamer library. Promiscuity values of the S100ome are defined towards the full H14 foldamer library (all the 256 possible combinations of 16 amino acids in two residues per foldamer building blocks) by averaging all the measured bound fraction values. Mean ± SEM are plotted on the y axis as a bar chart. The promiscuity average was arbitrarily chosen as threshold value for the promiscuous group (S100A2, S100A4, S100P, S100A1, S100A6, S100A5, S100B, S100A10), while the rest of the S100ome is less promiscuous exhibiting fewer binding events.
