Figure 2
[11C]CFN displacement study with two doses of IV NLX (baseline, n = 3; 0.035 mg/kg, n = 3; 0.17 mg/kg, n = 3). Averaged time-activity curves in the cerebellum (A) and thalamus (B) were generated in standard uptake value (SUV, g/mL). Averaged SUVs of thalamus to cerebellum ratios (SUVr) for baseline and the two NLX doses (C). Dose-dependent displacement rate was expressed as gradient change after NLX post-treatment (D). NLX was administered at 15 min after [11C]CFN injection.
