Figure 4

MOR occupancy profiles after IV NLX for two doses (circle, 0.035 mg/kg; rectangle, 0.17 mg/kg). Occupancy data averaged for each time point were plotted with a sigmoidal function. NLX 0.035 mg/kg corresponds to 0.4 mg HED and NLX 0.17 mg/kg to 2 mg HED. Error bars correspond to standard deviations.