Table 1 Plasma pharmacokinetics of NLX for two doses (0.035 and 0.17 mg/kg, IV) in healthy rats. Values correspond to means (standard deviations).

From: Naloxone’s dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain

Dose (mg/kg)

Half-life (min)

Tmax (min)

Cmax (ng/mL)

AUC (0–inf)

0.035 (n = 3)

7.3 (3.5)

6.8 (3.3)

12.4 (1.7)

53.2

0.17 (n = 3)

16 (5.8)

15.0 (5.0)

50.5 (1)

489.6

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