Table 1 List of top 10 canonical pathways for the common DEGs.
Ingenuity canonical pathways |  − log(p-value) | Ratio | z-score | Molecules |
|---|---|---|---|---|
Cell Cycle: G1/S Checkpoint Regulation | 4.16 | 0.113 | 0 | BTRC, CCNE2, CDKN1A, GNL3, MYC, NRG1, PAK1IP1 |
GADD45 Signaling | 3.64 | 0.211 | NULL | CCNE2, CDKN1A, GADD45B, PCNA |
p53 Signaling | 3.39 | 0.0854 | 1 | CDKN1A, COQ8A, GADD45B, GNL3, PCNA, PIK3C2G, SFN |
Ferroptosis Signaling Pathway | 3.35 | 0.0734 | − 1.414 | CDKN1A, GCH1, H2AX, HMOX1, HSPB1, PRKAG2, SLC1A5, SLC7A11 |
ErbB Signaling | 3.27 | 0.0814 | 1.134 | AREG, EREG, HBEGF, MAP2K3, MAP2K6, NRG1, PIK3C2G |
Cell Cycle Regulation by BTG Family Proteins | 2.69 | 0.121 | NULL | CCNE2, NOCT, PPM1L, PPP2R2B |
Valine Degradation I | 2.39 | 0.15 | NULL | ACADSB, BCAT2, BCKDHB |
Hereditary Breast Cancer Signaling | 2.37 | 0.0569 | NULL | CDKN1A, GADD45B, H2AX, NPM1, PIK3C2G, SFN, SMARCA2 |
Xenobiotic Metabolism Signaling | 2.36 | 0.0442 | NULL | FMO1, FMO2, GSTM2, HMOX1, MAP2K3, MAP2K6, MAP3K8, PIK3C2G, PPM1L, PPP2R2B |
NRF2-mediated Oxidative Stress Response | 2.35 | 0.0471 | 0.378 | CBR1, FMO1, FOSL1, GSTM2, HMOX1, MAFF, MAP2K3, MAP2K6, PIK3C2G |
