Figure 1
From: Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice
Effects of topical administration on Nasal Potential Difference in F508del Cftrtm1Eur mice. (a) Tracing of Nasal Potential Difference performed in a F508del Cftrtm1Eur mouse after topical instillation once a day for 48 h of NaCl 0.9% (left panel) or NaCl 0.9% followed by c407 10 µM (right panel). (b) Summary of Nasal Potential Difference changes after perfusion of Inh-172 5 µM in low Cl− solution (∆ Inh-172) in mice treated with NaCl 0.9% (n = 13) or NaCl 0.9% followed by c407 10 µM (n = 13).
